Betty Boop gets into a fight with her parents, runs away from home with her friend Bimbo, and sings excerpts of the Harry Von Tilzer song "They Always Pick on Me" (1911) and the song "Mean to Me" (1929).
Betty and Bimbo end up in a cave where a ghost walrus, with Cab Calloway's voice, sings "Minnie the Moocher" and dances to the song. Calloway is joined in the performance by various ghosts, goblins, skeletons, and other frightening things. Betty and Bimbo are subjected to skeletons drinking at a bar; ghost prisoners sitting in electric chairs; a mother cat with skull-like eyes feeding her equally empty-eyed kittens; and so on. Betty and Bimbo both change their minds about running away and rush back home with every ghost right behind them. The film ends with Calloway performing the instrumental "Vine Street Blues".